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The multiple regression analysis of MPV and other risk factors was performed. There were positive correlations between anti-TPO and MPV levels (r = 0.246, P = 0.042), and between anti-tiroglobulin and MPV levels (r = 0.256, P = 0.033). To assess the correlation with MPV, a Pearson's correlation analysis was performed on each variable. Mean MPV levels were significantly higher in the euthyroid Hashimoto's thyroiditis group than in the control patients (8.8 ± 1.05 and 7.9 ± 0.79 fl, respectively P = 0.0001). Serum triglyceride levels were significantly higher in the study group than in the control group (133.81 ± 91.50 and 90.18 ± 41.15 mg/dl, respectively P = 0.015). There were no significant differences in terms of serum thyroid-stimulating hormone (TSH) (1.76 ± 0.79 and 1.85 ± 1.14 uIU/ml, respectively), FT3 (3.10 ± 0.37 and 3.29 ± 0.76 pg/ml, respectively) and FT4 (1.22 ± 0.42 and 1.46 ± 0.78 pg/ml, respectively) levels between the study and the control groups.
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Anti-TPO and anti-tiroglobulin levels were significantly higher in the study group (anti-TPO 428.32 ± 668.39 IU/ml in the euthyroid Hashimoto's thyroiditis group 14.85 ± 9.66 IU/ml in the control group, P = 0.001 anti-tiroglobulin 320.46 ± 796.05 IU/ml in the euthyroid Hashimoto's thyroiditis group, 21.28 ± 26.24 IU/ml in the control group, P = 0.09). There were no significant differences in age (33.88 ± 12.87 and 30.18 ± 12.43 years, respectively P > 0.05) and BMI (23.55 ± 3.34 and 22.25 ± 3.65 kg/m, respectively, P > 0.05) between the study and the control groups. All the study participants were evaluated by biochemical and platelet parameters. Anti-thyroid peroxidase (anti-TPO) antibody and anti-tiroglobulin antibody were positive. None of the study patients was subjected to levothyroxine replacement therapy. All patients with euthyroid Hashimoto's thyroiditis were at euthyroid state. Fifty-one euthyroid patients with Hashimoto's thyroiditis attending our outpatient clinic of the endocrinology department, and 51 age and BMI-matched healthy individuals were included in this study. In this study, we aimed to investigate MPV levels in euthyroid Hashimoto's thyroiditis patients.
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MPV possibly is a simple way to estimate platelet activity. Mean platelet volume (MPV) is the measure of platelet size.
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